Dosing & Administration

• If a dose of PIQRAY is missed, it can be taken with food within 9 hours after the time it is usually taken. After more than 9 hours, skip the dose for that day. The next day, take PIQRAY at the usual time¹

• If the patient vomits after taking the dose, advise the patient not to take an additional dose on that day, and to resume the dosing schedule the next day at the usual time¹

Effect of other drugs on PIQRAY¹

CYP3A4 inducer (eg, rifampin)

• Coadministration of PIQRAY with a strong CYP3A4 inducer decreases alpelisib concentration, which may reduce alpelisib efficacy

• Avoid concomitant use of strong CYP3A4 inducers and consider an alternative concomitant drug with no or minimal potential to induce CYP3A4

BCRP inhibitors (eg, cyclosporine A)

• Coadministration of PIQRAY with a BCRP inhibitor may increase alpelisib concentration, which may increase the risk of toxicities

• Avoid the use of BCRP inhibitors in patients treated with PIQRAY

• If unable to use alternative drugs, when PIQRAY is used in combination with BCRP inhibitors, closely monitor for increased adverse reactions

Effect of PIQRAY on other drugs¹

CYP2C9 substrates (eg, warfarin)

• Coadministration of PIQRAY with CYP2C9 substrates may reduce plasma concentration of these drugs

• Closely monitor when PIQRAY is used in combination with CYP2C9 substrates where decreases in the plasma concentration of CYP2C9 substrates may reduce activity of these drugs